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Location - Cambridge, MA.

Editas is seeking a highly motivated Research Associate I/II to join our ex vivo pharmacology group. The candidate will be responsible for conducting preclinical animal studies to support the development of gene-editing based ex vivo cell therapies in multiple disease areas, including sickle cell disease and beta-thalassemia. The successful candidate will be part of a dynamic team and will interact with the discovery, platform, process development groups, as well as contract research organizations. The successful candidate should demonstrate strong work ethics and ability to work in a fast-paced and highly demanding work environment.

Key Responsibilities

·         Execute in vivo studies including xenotransplantation of human hematopoietic stem and progenitor cells in immunodeficient mice.

·         Perform routine injections (sc, ip, iv) in mice, monitor animal health, collect blood samples, perform necropsies.

·         Establish new animal models as needed.

·         Culture primary cells and cell lines.

·         Perform basic molecular biology work such as DNA and RNA extraction and PCR.

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Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective genome level molecular modification to treat the underlying cause of a broad range of diseases.

This new role on the Technical Development and Manufacturing team provides a unique opportunity to contribute to Editas’ efforts to develop safe and effective cellular therapies using CRISPR-based gene editing technologies. We are seeking a talented and highly-motivated individual to perform experiments that generate data to guide development of processing methods and standard operating procedures (SOPs) for the preparation of cellular therapies for translational clinical studies. Candidate must be experienced with aseptic technique and be versatile to assist in the development of processes for autologous or normal donor cellular products derived from different lineages of cells (T cells, HSCs, etc.).

Key Responsibilities:

·         Perform experimentation to develop cellular processes to support gene-edited cell therapy programs at Editas

·         Assist in data compilation, analysis, and drafting technical reports to support developed cellular processes for clinical manufacturing

·         Work with Analytical Development to generate and analyze data to develop understanding of most relevant critical quality attributes of cellular products to guide safe and effective clinical testing and process control strategies

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Location - Cambridge, MA

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective genome level molecular modification to treat the underlying cause of a broad range of diseases.

We are seeking a talented and highly-motivated individual to join the Editas Manufacturing team to help develop methods and standard operating procedures (SOPs) protein and nucleic acid formulations in collaboration with the Research team. The formulation components will be manufactured following applicable GMP principles and will be characterized for safety, purity, and activity to enable their use in translational clinical studies.

Key Responsibilities:

·         Work in a cross-functional team to develop and optimize processes appropriate for protein and nucleic acid formulations to support gene-edited cell therapy programs at Editas

·         Adapt and optimize protein purification processes for manufacturing of CRISPR nuclease proteins

·         Work with Analytical Development team to generate and analyze data for individual CRISPR gene-editing components (nuclease proteins and guide RNAs), and of assembled ribonucleoprotein complexes

·         Collaborate with Editas colleagues in Platform and Pipeline teams to evolve research protein and nucleic acid reagents and put formulation process development to define critical component parameters required to achieve successful clinical translation

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Location - Cambridge, MA

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective genome level molecular modification to treat the underlying cause of a broad range of diseases.

This role on the Technical Development and Manufacturing team provides a unique opportunity to contribute to Editas efforts to develop safe and effective cellular therapies using CRISPR-based gene editing technologies. We are seeking a talented and highly-motivated individual to design and perform experiments that generate data to guide development of methods and standard operating procedures (SOPs) for the preparation of ribonucleoprotein (RNP) complexes comprised of a specific CRISPR nuclease protein and corresponding guide RNA.  The RNP complexes will be manufactured following applicable cGMP principles and will be characterized for safety, purity, and activity to enable their use in translational clinical studies.

Key Responsibilities:

·         Lead cross functional team to develop processes appropriate for manufacturing of RNP complexes to support gene-edited cell therapy programs at Editas

·         Develop manufacturing SOPs for RNP complexation processes to support clinical testing

·         Work with Analytical team to generate and analyze data to determine optimal buffer formulations and storage conditions of individual CRISPR gene-editing components (nuclease proteins and guide RNAs),... More Info

Location – Cambridge, MA

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.   

We are seeking a highly motivated and innovative research associate with molecular biology and cell biology expertise to support the development of gene editing-based therapies. The successful candidate will contribute as part of a dynamic, multidisciplinary discovery team dedicated to the development of novel first in class of therapeutics. In this role you will work with a team within the research group to develop gene editing approaches to treat inherited ophthalmic disorders. The successful candidate is expected to have proven practical experience in molecular biology and cell culture. The candidate should be a scientifically motivated self-starter, capable of working with minimal supervision. Strong communication skills, and the ability to work in a fast-paced and team-oriented environment will also be vital. The position requires flexibility and the ability to work effectively in a multi-disciplinary team.

Key Responsibilities:

·         Design and implement molecular biology assays (DNA/RNA isolation, PCR, sequencing, RT-qPCR, gene expression analysis, ELISA, Western Blotting)

·         Mammalian tissue culture, transfection and transduction

·         Conduct cell-based assays (Flow... More Info

Location - Cambridge, MA

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level. 

The clinical trials associated with these development programs will be performed on a global scale in coordination with Contract Research Organizations (CROs).  These trials will be submitted to health care regulatory authorities around the world such as the United States Food and Drug Administration (FDA) and the European Medicines Agency (EMA).  We are seeking a Manager of Clinical Operations with a keen attention to detail who will be responsible for overseeing clinical operations/clinical trial management within our lead ophthalmology program.  Under the guidance of Clinical Operations management, the individual will coordinate, track, and manage daily activities for oursourced clinical trials.

Key Responsibilities:

·        Manage and provide daily oversight of full service CROs and third-party vendors to ensure successful clinical trial implementation and execution.

·        Collaborate with consultants and contractors to R&D.

·        Manage and communicate to senior management overall clinical operations plan for clinical early phase trials including timelines, internal and external resources/costs, and critical deliverables.

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Director/Associate Director, Clinical Operations

The Director/Associate, Director, Clinical Operations will provide strategic input and operational expertise to the Clinical Development Plans supporting the overall clinical strategy. The Associate Director is responsible for the planning, implementation, and conduct of clinical trials. The Associate Director is accountable for the day-to-day operations of clinical trials including, but not limited to, feasibility, study start up, enrollment, and close out activities. The Associate Director will manage the clinical project team members to ensure adherence to overall project timelines and budget.

Key Responsibilities:

Clinical Trial Management

·        Serve as the clinical point person managing protocol execution, including the oversight of contract research organizations (CROs), vendors, and consultants that are involved with the clinical trial.

·        Partner with the Medical Lead to develop high quality, operationally clear study synopsis/protocol, ensuring all relevant stakeholders (both internal and external) are involved and contributing.

·        Provide expert clinical operations input into clinical documents related to the drug development process including IBs, INDs, study synopsis & protocols, informed consents, interim and final clinical study reports, applicable sections of NDAs and/or MAAs.

·        Provide strategic and... More Info

Location – Cambridge MA.

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.  This exciting position will help develop and assess editing candidates used for the treatment of genetic diseases in an entrepreneurial, fast-paced team environment.

In this role, you will use your experience in cellular assay development and automation systems to contribute in building a robust platform that finds and characterizes genome editing components (like guide RNAs and Cas9 variants).  Flexible implementation of various medium and high throughput technologies to fit the problem is crucial; and so a deep understanding of the technologies and their applications is required.  Experience with cellular assay development, automated liquid handlers, cell culture, and data management are highly desired.  Familiarity with Next Gen Sequencing methodologies is a plus.

The position requires flexibility and the ability to work effectively in a multi-disciplinary team.  Capacity for creativity and innovation to achieve company goals combined with excellent written and verbal communication skills are highly desired.

Location - Cambridge, MA

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.  Editas is seeking a Scientist/Senior Scientist with a focus on research and development of CRISPR/Cas9-based ocular medicines.

The candidate will be part of the ophthalmology discovery group that is responsible for discovering medicines for  both inherited retinal degenerations and genetically treatable ocular diseases. The successful candidate will interact effectively with the pre-clinical and platform groups, as well as external collaborators.  The individual will provide scientific expertise and guidance for target selection, early research candidate selection, and transition into early clinical development. 

A successful candidate will demonstrate extensive knowledge in molecular and cellular pathways in ophthalmology.  Experience with cellular and animal models is essential as well as experience with gene editing and molecular skills.

Key Responsibilities:

·        Develop therapeutic hypotheses and experimental therapies based on these hypotheses that address unmet needs in ophthalmology

·        Lead a cross functional team of scientists to discovery novel gene editing therapies from project initiation to development candidate nomination

·        Work effectively with preclinical... More Info

Location – Boulder, CO

Editas Medicine is a transformative company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying genetic cause of disease. 

We are currently building an informatics platform that spans a wide range of our needs ranging from LIMS development, lab automation, and data pipeline management.  To support our platform Editas is seeking to hire an informatics developer with proven expertise in designing and implementing a LIMS to handle a variety of lab functions and experiments (NGS, etc.).  They should also have knowledge and experience managing scientific data and processes, building automation, and interacting with scientists and researchers.  Experience with modern development practices, Tableau, web and web services development and cloud computing is highly desirable as well.

Professional experience developing Java software in biotech required.  You should be familiar with terms like JAXB, JSON, GIT, Jersey, AWS, Swagger, web services, serverless and HTML5.

Key Responsibilities:

·        Building and supporting a LIMS to support the laboratory and scientists

·        Leveraging cloud-based computing to promote inputs to analysis pipelines and data workflows

·        Interacting with scientists and translating their needs into software design and tools

Location – Cambridge, MA

Editas Medicine is a transformative company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying genetic cause of disease. 

We are currently building an informatics platform that spans a wide range of our needs ranging from LIMS development, lab automation, and data pipeline management.  To support our platform Editas is seeking to hire an informatics developer with proven expertise in designing and implementing a LIMS to handle a variety of lab functions and experiments (NGS, etc.).  They should also have knowledge and experience managing scientific data and processes, building automation, and interacting with scientists and researchers.  Experience with modern development practices, Tableau, web and web services development and cloud computing is highly desirable as well.

Professional experience developing Java software in biotech required.  You should be familiar with terms like JAXB, JSON, GIT, Jersey, AWS, Swagger, web services, serverless and HTML5 

Key Responsibilities:

·        Building and supporting a LIMS to support the laboratory and scientists

·        Leveraging cloud-based computing to promote inputs to analysis pipelines and data workflows

·        Interacting with scientists and translating their needs into software design and tools

Location - Cambridge, MA

IT Business Analyst

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.  

Editas Medicine is looking for an IT Business Analyst with a focus on Enterprise applications. This candidate will play a key role in the expansion and support of our ERP suite across the Finance, HR, Procurement, Contracts, and FP&A functions. This strategic position will be part of a strong, integrated G&A team and will play a pivotal role in building systems and capabilities across the company 

The ideal candidate must possess strong business analytical skills and will work with the business process owners to evaluate requirements, recommend process improvements and configure the ERP solutions. This IT Business Analyst role has responsibilities within each phase of the ERP Transformation project life cycle including user meetings, requirements gathering, development, testing, implementation, and go-live.

The IT Business Analyst provides outstanding client service and contributes to the organization’s mission of utilizing information technology to improve patient care.

Key Responsibilities:

·         Influence and support the overall roadmap for the ERP Product portfolio of Editas Medicine with a focus on G&A business processes.

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Location - Cambridge

Editas Medicine’s mission is to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modifications to treat the underlying cause of a broad range of diseases. Their technology, known as CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats), has the potential to achieve accurate, directed changes in DNA and fulfill the promise that started with the sequencing of the human genome – the potential to treat

diseases at their source by editing genes. The Company has generated substantial expertise and intellectual property that will uniquely allow it to translate the promise of CRISPR into transformative human medicines.

Key Responsibilities:

The Senior Vice President or Vice President of Finance is a key leader of our dynamic financial organization which is dedicated to excellence and integrity and focused on supporting Editas’ growth strategy. S/he will be responsible for financial reporting, accounting operations, financial

systems and controls, and managing people and processes related to SEC filings, auditing firms, tax preparers, and asset managers.

Specifically, the SVP or VP of Finance / Controller will:

·         Lead the accounting team, ensuring high performance and fostering individual and team development.

·         Responsible for supporting and enhancing a collaborative, innovative, and disciplined finance organization.

·         Ensure the finance organization delivers timely financials in accordance with GAAP.

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Location - Boulder, CO

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.   

We are seeking a highly motivated and innovative research associate with analytical chemistry or bioanalytical expertise to support the development of gene editing-based therapies. The successful candidate will contribute as part of a dynamic, multidisciplinary discovery team dedicated to the development of a novel class of therapeutics. The successful candidate is expected to have proven practical experience in chemistry or biochemistry, specifically in purification and analysis of RNA and RNA derivatives. The candidate should be a scientifically motivated self-starter, capable of working with minimal supervision. Strong communication skills, and the ability to work in a fast-paced and team-oriented environment will also be vital.   

Location – Cambridge, MA

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.   

Editas is seeking a highly motivated facilities management professional to be responsible for building operations at our Cambridge, MA and Boulder, CO locations. This role will manage space and capacity planning, moves, access control, security, building maintenance and day to day operations. The candidate will help prepare and manage the site operating budgets, manage relevant vendor relationships, establish standards across sites and act as a point of contact with our building management companies.

Key Responsibilities:

• Day to day operations of our Cambridge location
• Ensure maintenance and upkeep schedules are adhered to
• Manage the Facilities service desk and ensure mutually defined SLA’s are managed and achieved
• Manage our building infrastructure vendors and management companies
• Develop capacity plans and budgets that meet the growth, scale and changing needs of the business
• Maintain a high level of employee satisfaction in a fast-paced environment
• Develop and test disaster recovery and business continuity plans
• Develop, implement and maintain building policies, procedures, and associated plans for security, safety and maintenance based on industry-standard best practices
• Partner with our... More Info

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.   

We are seeking an innovative Scientist with experience in medicinal chemistry, bioorganic chemistry or organic chemistry to join our Medicinal Chemistry effort and help drive drug discovery and development of novel CRSPR therapeutics. The successful candidate is expected to have proven experience in chemistry related to biologically active compounds as demonstrated by peer reviewed publications (including patents), and presentations at professional conferences.  In this position you will be part of a collaborative effort in our Boulder Colorado chemistry facility, and with our colleagues in Cambridge, to design, synthesize and assay new CRISPR technologies.  You will be expected to travel to Cambridge several times a year and to scientific conferences to present scientific accomplishments.  In our fast-paced environment you must have excellent communication skills. Those who are highly motivated self-starters and thrive in a team environment but are capable of working with minimal supervision are encouraged to apply. 

This is an exciting opportunity to join Editas Medicine, a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level. The Pharmacology group in Preclinical Science is seeking a highly talented and motivated Scientist I/II who will be responsible for designing and conducting in-life imaging and functional tests in support of development of novel CRISPR/Cas9-based therapeutics for Ophthalmology indications and other disease areas. This individual will work collaboratively with internal multi-disciplinary team members and external partners to drive and deliver results to support preclinical and clinical development initiatives. The position will report directly to the Associate Director of Preclinical Pharmacology.

Key Responsibilities:

·         Extensive hands-on experience in ocular imaging and surgical techniques and use of ophthalmic equipment.

·         In-depth knowledge of functional and structural endpoint measurements of retinas using optical coherence tomography (OCT), electroretinograms (ERGs), ocular fundus photography, fluorescein angiography, and slit lamp biomicrography.

·         Experience with animal models of inherited retinal disorders and use of gene therapy vectors to treat these disorders is required.

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Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.

We are seeking an experienced program management professional to serve as Program Leader for one or more of Editas’ development programs. The ideal candidate will have a strong scientific background and experience developing drugs in the Gene Therapy, SiRNA Rare Disease, Immunology or Oncology space and leverage that experience to play a key role on Editas’ cross-functional teams, helping to translate scientific ideas into new medicines for patients. This role is highly cross-functional and will report to the Vice President, Program Management.

Key Responsibilities:

·        Serve as Program Leader... More Info

Location – Cambridge, MA.

Editas is seeking a Quality Assurance Manager within the Technical Development and Manufacturing team to manage the continued development of the internal Quality Management System. Reporting to the Head of Quality, the QA Manager will be responsible for supporting the development and implementation of the Quality Management System at Editas, eventually becoming responsible for oversight of all internal QMS activities as well as supporting GMP efforts conducted at Contract Manufacturing Organizations (CMO). This is an opportunity for an individual experienced in the drug development environment and, more specifically, GMP documentation requirements, to step in and manage a developing and early stage QMS while having exposure to broader QA responsibilities and significant QA skill set development.

This position's responsibilities include but are not limited to: overseeing all internal and external quality assurance activities including: manage the evolving internal document management system, provide compliance oversight to applicable internal activities, maintain internal documentation processing functions and organizational records management. In addition, the qualified candidate will be expected to identify gaps in the current quality system, propose viable solutions and lead the process for improvement. This position will eventually also function as a QA lead on various project teams.

Key Responsibilities:

·         Process internal controlled documents including but not limited to: SOP’s, forms, templates, internal reports, engineering documents, etc.

·         Assist with SOP and other controlled document generation including authoring revisions, QA review, word processing... More Info

Location - Cambridge, MA.

Editas is seeking Associate Director/Director within the Technical Development and Manufacturing team to lead the Quality Control function and support Editas’ engineered cell and viral vector products that incorporate CRISPR gene-editing technologies. Reporting to the Head of Quality, the qualified candidate will be responsible for overseeing Quality Control activities at the company’s Contract Manufacturing Organizations (CMOs) and Contract Testing Organizations (CTOs), as well as developing an internal QC analytical laboratory. 

This position's responsibilities include but are not limited to: overseeing all internal and external quality control activities including testing and releases of raw materials, intermediates and APIs, supporting IND enabling and GMP production activities, executing proper life-cycle management of analytical methods (i.e. validation, transfer, review, approval, changes), leading OOS/OOT investigations, manage stability programs and ensure compliance to the applicable compendial and regulatory requirements. The AD/Director of QC also ensures compliance of the analytical laboratories and operations to the most current data integrity requirements, drives continuous improvement and implementation of industry best practices to maximize efficiency.

Key Responsibilities:

·         Plan, coordinate, and manage routine testing of in-process, final product and stability study samples in accordance with Standard Operating Procedures and approved methods (HPLC, Q-PCR, activity assays, cell-based bioassays, Osmolality, pH, ELISA, etc.)

·         Coordinate with the Analytical Methods Development group to develop, review and approve the phase appropriate qualification/validation of analytical procedures and the transfer of such procedures into QC or to external laboratories

·        Develop therapeutic hypotheses and experimental cellular therapies based on these hypotheses that address unmet needs in immunology and/or oncology

·        Lead a cross functional team of scientists to discovery novel cell-based therapies from project initiation to development candidate nomination

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Location - Cambridge, MA

Editas Medicine is a transformative genome editing company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level. 

The successful candidate will lead the Bioanalytical group accountable for timely and effective bioanalytical support for all programs in preclinical and clinical development, balance long-term strategy with tactical and detailed technical decision-making.  This individual will develop and implement strategic program plans and is responsible for design, technical oversight, outsourcing, technology transfer, validation, and documentation for Regulatory submission purposes of bioanalytical methods including ELISA, Luminex, ADA, NAb, ELISPOT, Biodistribtuion etc. The individual will actively participate in program teams, as well as collaborate effectively across functions. The successful candidate shall demonstrate a proven track record in development experience with biologics, nucleic acid-based, or gene therapy products through IND/BLA and solid understanding of FDA/EMA guidelines.  This individual will be highly analytical, goal-oriented, and timeline sensitive while maintaining high quality standards and process.

Key Responsibilities:

·        Develop and implement bioanalytical strategy in support of development of viral (AAV) and non-viral delivered CRISPR medicine

·        Design, execute, interpret and report bioanalytical studies to support drug candidate validation in late-stage research, preclinical and clinical development at all stages

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