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Editas Medicine is a transformative genomic medicine company with a mission to translate its genome editing technology into a novel class of human therapeutics that enable precise and corrective molecular modification to treat the underlying cause of a broad range of diseases at the genetic level.

We are seeking an experience alliance management professional to serve as the key interface between Editas and its partners and to enable both parties to realize the full potential of each alliance.  The ideal candidate will have substantial experience managing multi-program corporate alliances, as well as alliances with academic institutions and technology-driven peers.  In addition, experience as the alliance manager at the smaller company in a significant corporate alliance is also desirable.  This role is highly cross-functional and will report to the Chief Financial Officer, with the Senior Director, Alliance Management being a key member of both the finance and business development teams.

Responsibilities

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Editas Medicine is seeking a highly motivated and experienced patent attorney to join its growing legal team. The patent attorney will advise Editas on a wide range of intellectual property matters, including patent preparation and prosecution, world-wide patent portfolio management, transactional, due diligence, and freedom-to-operate analyses. The successful candidate will possess strong leadership, analytical, and communication skills, including the ability to work closely with management across multiple R&D teams, as well as the business development team. This position will report to the Vice President of Legal.

Primary Responsibilities

·         Developing and executing clear, informed, and sophisticated intellectual property strategies and counseling Editas clients engaged in its platform technology and therapeutic product development functions

·         Advising the Vice President of Legal and management team regarding Editas’ multi-faceted gene editing intellectual property portfolio

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Editas is seeking a computational biologist to join the team.  In this role, you will develop, implement, and run algorithms for our research and clinical genome editing platform based on CRISPR/CAS9 and CPF1.  You will work closely with biologists and our informatics group to build robust pipelines and conduct analyses that span a broad range of Next Gen Sequencing (NGS) methodologies as well as other data intensive methods. The position requires strong fundamentals in engineering, genetics / genomics, and biology. Excellent written and verbal communication skills are crucial.

Responsibilities will include:

·         Working closely with project teams, run data analysis pipelines and provide expert analysis to the team

·         Develop specifications, write and review code, and produce documentation for NGS sequence analysis in a variety of applications

·         Automate pipeline analysis and integrate our LIMS system into pipelines

·         Present on methods and results to internal scientists & leaders

·         Write reports and regulatory documentation

Editas is searching for a highly-motivated, resourceful, technical thinker to join our growing Finance team.  This role will be responsible for leading the Company’s financial planning and analysis duties, internal financial reporting and also for providing SEC reporting advice.    

Reporting to the Vice President, Finance, the Director of FP&A will be a key business partner to Editas’ R&D organization and, in coordination with other members of the Finance team, help to support executive management of Editas as a whole.

Primary duties include, but are not limited to:

Lead the annual budget and forecasting process for all departments

Serve as a strategic business partner with our R&D team providing monthly reporting on key areas of the business, including analysis of actual results, key trends impacting the business, and projections of future spend

Prepare monthly flash and management reports

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We are seeking a highly motivated and innovative research associate with molecular biology, cell culture, and automation expertise to support the development of gene editing-based therapies. The successful candidate will contribute as part of a dynamic, multidisciplinary discovery team dedicated to the development of a novel class of therapeutics. The successful candidate is expected to have proven practical experience in molecular biology and mammalian cell culture. The candidate should be a scientifically motivated self-starter, capable of independently conceiving, conducting, and critically analyzing his/her own innovative research with minimal supervision. Strong presentation skills, communication and the ability to work in a fast-paced and team-oriented environment will also be vital.

Editas is seeking a Scientist for the Technical Development and Manufacturing team to perform analytical characterization of complex large biomolecules, including long guide RNAs, nuclease proteins, RNA/protein complexes, and AAV vectors.  The qualified candidate will report to the Associate Director of Process Analytical Development and will develop analytical methods, generate data, write technical reports and SOPs to advance Editas’ engineered cell and viral vector products that incorporate CRISPR gene-editing technologies.

The successful candidate will work cross-functionally with internal project and platform teams, with external partners, and with CMOs to design assays and to generate, trend and interpret analytical data required to more thoroughly understand the biophysical parameters of our complex products.  A key goal will be to develop the most appropriate analytical strategies, aligned with internal and external process development teams and quality groups, to define the critical quality attributes of our various process intermediates and drug products.  Another key goal will be to support work on formulation and stability of guide RNAs, nuclease proteins, RNP complexes and AAV vectors.  Analytical data will be used to develop analytical testing procedures, qualify assays, and to write technical reports, regulatory documents and manufacturing SOPs, according to scientific and regulatory guidance (e.g., ICH, FDA, USP, EP), which will be transferred to CMO partner organizations. 

Editas is seeking an experienced computational biologist to join our team.  In this dynamic role, you will lead a team of computational biologists developing and implementing algorithms for our clinical genome editing platform based on CRISPR/CAS9 and CPF1.  You will work closely with biologists, platform leads, and our informatics group to build robust pipelines that span a broad range of Next Gen Sequencing (NGS) methodologies as well as other big data methods (eg: FACs, multi-analyte antibody detection, imaging, and screening). The position requires flexibility, creativity, and the ability to work effectively across multiple disciplines in a fast-paced team environment.  Excellent written and verbal communication skills are crucial.

Responsibilities will include:

·         Lead and develop our computational biology group

·         Define and prioritize computational biology needs across the company

·         Plan, write, and review code

·         Present on methods and results to internal scientists & leaders, external collaborators, and at conferences

·         Write papers, reports, and regulatory documentation

Editas is seeking a highly-motivated and experienced cell product manufacturing expert to join as Director of Cell Process Development.  This person will report to the VP of Technical Development and Manufacturing and will guide Editas efforts to develop safe and effective cell therapies using CRISPR-based gene editing technologies.  Candidate must be versatile and able to work with research colleagues to develop processes for autologous or normal donor cell products derived from different lineages of cells (T cells, HSCs etc.).

The Director will work with Editas colleagues to draft RFPs, perform diligence (including site visits), to identify external CMO partners required to bring innovative genome-edited cell therapies to the clinic and to market.  Previous experience with process technology transfers to cell product CMOs and managing such relationships desirable.

Successful candidate will demonstrate proficiency with quality and regulatory requirements of engineered cell products, including thorough understanding of relevant ICH guidelines.  The candidate will be responsible for writing the CMC sections of briefing books, INDs and other regulatory filing documents and will interact with global regulatory agencies.  Experience in both early stage development and late stage/commercial development with strong record of successful IND/CTD/BLA/MAA filings is expected.

Responsibilities include, but are not limited to:

·         Manage and provide oversight to external manufacturing partners to ensure compliance with established manufacturing agreements.

·         Oversee and lead interactions with external manufacturing partners to assure that quality and compliance related matters meet... More Info

Successful candidate will be responsible for helping to develop and assess tools to be used for the treatment of rare genetic diseases in an entrepreneurial, fast-paced team environment.  In this role, you will be using your experience in next generation sequencing technologies (library prep, quality control, sequencing hardware) and targeted nucleic acid detection technologies (qPCR, droplet based PCR) to help develop techniques and processes for the successful translation of this technology into the clinic.  The candidate will work closely with the development team to optimize and scale up new methodology and the automation team to transition protocols into Production.  Experience with clinical materials, genomic DNA prep and developing new assays would be a plus. The position requires flexibility, creativity, and the ability to work effectively in a multi-disciplinary team, as well as excellent written and verbal communication skills, and a capacity for creativity and innovation to achieve company goals.

The successful candidate will be part of the Immunosafety and Bioanalytical Development group in Preclinical Science at Editas Medicine, focusing on development and execution of immunoassays and cell-based methods for the characterization of CRISPR/Cas9-based therapeutics, to support drug candidate validation in late-stage research and translational/clinical development at all stages.

The successful candidate shall demonstrate extensive working experience with a series of immunological assays that include ELISA, multi-color flow cytometry, immune cell isolation and culture, and cell-based assays to evaluate immune responses. Strong data organization and analysis skills are also required.

Editas is seeking a Vice President of Ocular Diseases to lead a group of biologists developing CRISPR/Cas9-based therapies primarily for ocular diseases.

This individual will report to Chief Scientific Officer and lead a group of 12 biologists to develop ocular therapies. The individual help develop the discovery biology strategy. The individual will then work collaboratively with internal multi-disciplinary team members and external partners to initiate programs consistent with the strategy, drive and deliver results on timelines, ensure that pharmacology and safety packages are fit for purpose, and present results both internally and externally, including publications.

The successful candidate shall have strong subject matter expertise in opthamology and drug discovery. The candidate will possess strong leadership skills, including the ability to develop talent and lead in a matrix organization. The candidate will also have excellent behaviors consistent with the Editas culture.

Editas is seeking a Vice President of Immunology to lead a group of biologists developing cell-based immunotherapies primarily for immunologic diseases using CRISPR/Cas9 technology.

This individual will report to Chief Scientific Officer, and lead a group of 12 biologists to develop cell-based therapies. The individual will be responsible for developing the discovery biology. The individual will then work collaboratively with internal multi-disciplinary team members and external partners to initiate programs consistent with the strategy, establish and deliver results on timelines, ensure that pharmacology and safety packages are fit for purpose, and present results both internally and externally, including publications.

The successful candidate shall have a strong technical background in T cell immunology for infectious diseases or autoimmune diseases, cell-based therapies, and drug discovery. The candidate will possess strong leadership skills, including the ability to develop talent and lead in a matrix organization. The candidate will also have excellent behaviors that exemplify Editas culture.

Reporting to the Chief Financial Officer, the successful candidate will lead all facets of business development at Editas Medicine, including partnerships and alliances, technology in-licensing and out-licensing and activities that support the diverse business needs of the organization.