Research Associate/Senior Research Associate, Process Chemistry Group – 1123 – Boulder, CO

Job Description

Location: Boulder, CO

What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We’re focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases.

We’re looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before.

Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.

The Editas Chemistry Group in Boulder, Colorado focuses on three key areas. The first is fundamental research aimed at driving the design of the next generation of therapies. The second is process development on declared lead gRNAs to enable a streamlined path to manufacturing. The third is GMP manufacture of high-quality guide RNAs to support internal clinical programs and those of our collaborators.

This new role on the Process Chemistry team in Boulder provides a unique opportunity to contribute to Editas’ efforts through the small-scale production of guide RNAs including synthesis, purification and downstream processing.

Job Description:
• Perform automated synthesis of oligonucleotides on a variety of scales and instruments including Bioautomation Mermade 12, Bioautomation Mermade 48X and GE Healthcare Akta 100 synthesizers.
• Perform process development and optimization.
• Conduct cleavage, deprotection and other downstream post-synthesis work-up procedures.
• Perform various SPE techniques for high throughput purification and processing of oligonucleotides.
• Perform various analytical techniques to ensure final product meets specifications including LCMS, UPLC and UV spectroscopy.
• Perform instrument and synthesizer preventative maintenance and repairs.
• Maintain an electronic laboratory notebook and miscellaneous documentation.
• Maintain reagent inventory.

Minimum Requirements:
• Experience in solid phase synthesis of oligonucleotides.
• Experience with laboratory automation.
• Excellent oral and written communication skills.
• Proficient with Microsoft Office programs.
• Technical troubleshooting and organizational skills.
• Ability to work effectively in a cross-functional team environment.
• Excellent time management.

• Requires a Bachelor’s degree in Chemistry with a minimum 2 years of relevant experience.

We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.