Scientist, Cellular Analytical Development – 1038 – Cambridge, MA

Job Description

Location – Cambridge, MA

What if you could repair broken genes? That is the question we ask ourselves at Editas Medicine. We’re focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases.

We’re looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before.

Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world? If the answer is yes, then Editas Medicine is the place for you.
This new role on the Analytical Development team provides a unique opportunity to contribute to Editas’ efforts to develop safe and effective cellular therapies using CRISPR-based gene editing technologies. We are seeking a talented and highly-motivated individual to lead development of in process and release cellular analytical assays, including molecular and flow cytometry based assays. Candidate must be experienced with molecular immunology and be versatile to assist in the development and transfer of qualified assays for autologous or allogeneic gene edited cellular products derived from different lineages of cells (T cells, HSCs, etc.).

Key Responsibilities:
•Perform multiplexed and high replication experimental strategies for development of cellular assays to support gene-edited cell therapy programs at Editas
•Perform data compilation, analysis, and drafting of technical reports and methods to support development of cellular assays for clinical manufacturing
•Work with Process Development to generate and analyze data to develop understanding of cellular product critical quality attributes to guide safe and effective clinical testing and process control strategies
•Assist with the technical transfer of cellular assays to Manufacturing or external CMOs and QC laboratories.

Minimum Requirements:
•Preferred PhD in life sciences, immunology preferred, and 3-5 years of industry experience
•Experience with blood and cellular methods including designing and running multi-color flow cytometry and cell culture differentiation methods.
•Experience with molecular biology methods including designing and running ddPCR and analysis of next generation sequencing.
•Strong organizational skills with the ability to multi-task, problem-solve, prioritize assignments, and adjust priorities to meet goals in a fast-paced environment
•Strong verbal and written communication skills
•Attention to detail and the ability to work individually, within a multi-disciplinary team in a matrix environment, as well as with external partners and vendors

Preferred Requirements:
•Development, qualification/ validation and/or technical transfer of GMP analytical methods for cellular therapies.
•Experience with isolating, culturing, and freezing cells using automated equipment and closed processes.
•Understanding of FDA, EMA and ICH regulations, industry standards and quality control principles for GMP operations.
•Attention to detail and the ability to work individually, within a multi-disciplinary team in a matrix environment, as well as with external partners and vendors

We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.