Scientist III/Sr. Scientist, Pharmacology – 1035 – Cambridge, MA

Job Description

Location: Cambridge, MA

What if you could repair broken genes?  That is the question we ask ourselves at Editas Medicine. We’re focused on translating the power and potential of the CRISPR/Cas9 and CRISPR/Cpf1 (also known as Cas12a) genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for many diseases.

We’re looking for talented, dedicated, passionate people to join our team and help us pioneer this field and do big, bold things that have never been achieved before.

Are you full of hope, possibilities, and a belief that, working together, we can truly revolutionize the development of medicines to help patients around the world?  If the answer is yes, then Editas Medicine is the place for you.

We are looking for an enthusiastic, innovative and experienced scientist to join Biological Development group to support research activities across multiple programs for cell therapy. The potential candidate would be expected to lead the path from the discovery research through early clinical development to evaluate the pharmacology of novel therapeutic approaches. Collaborative interactions with therapeutic area research, preclinical safety, biomarker (imaging or biochemical) and clinical development teams are critical to success in the role.

The main responsibilities of the candidate are to lead the strategy, planning and execution of activities related to preclinical pharmacology.  The activities include 1) Strategy for and oversight of animal model development and characterization in the areas of of ophthalmology and neurology; 2) Design experiments and develop assays critical to understand in-vivo therapeutic activity, efficacy, and PK/PD properties; Suggest refinements and optimization to in-life procedures, based on study requests from project teams; 3) Perform preclinical proof-of-concept and interact with clinical development team to design and supervise IND-enabling studies; 4) Experience managing studies remotely through CRO collaborators; 5) Documentation of assay development and animal study results; responsible for write-up or review of pre-clinical pharmacology-related section of IND.

Position Requirements:

  • PhD in pharmacology (or related disciplines) with a minimum of 8 years of industrial experience. Experience in biologics, cell or gene therapy is a plus.
  • A broad knowledge and proven ability to develop/evaluate disease models for efficacy studies
  • Ability and commitment to high-quality research and the execution of research plans in a timely and organized manner
  • Strong written and communication skills; and an ability to collaborate effectively with a diverse team in a fast-pace and dynamic environment

We are an equal opportunity employer offering a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.