EDITAS MEDICINE’S NEWSROOM
Editas Medicine is a leading gene editing company dedicated to developing gene edited medicines for people living with serious diseases around the world. Check out our press releases and other company information to stay apprised of the latest news.
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November 4, 2024
Editas Medicine Announces Third Quarter 2024 Results and Business Updates
October 22, 2024
Editas Medicine Announces Progress Towards 2024 Goals, Including Achievement of In Vivo Preclinical Proof of Concept and Strategic Update
October 21, 2024
Editas Medicine and Genevant Sciences to Collaborate to Develop Novel mRNA-LNP Gene Editing Therapeutics
October 18, 2024
Editas Medicine to Host Strategic Update Webinar to Detail Progress Towards 2024 Goals, Including Achievement of Establishing In Vivo Preclinical Proof of Concept
October 3, 2024
Editas Medicine Announces $50+ Million Monetization Financing with DRI Healthcare Trust
August 28, 2024
Editas Medicine to Participate in Upcoming Investor Conferences
Posters and Presentations
We ground our work in a wide range of fundamental scientific knowledge.
June 15, 2024
R. Hanna, M.D., et al. Reni-cel, the first AsCas12a gene-edited cell therapy, led to hemoglobin normalization and increased fetal hemoglobin in severe sickle cell disease patients in an interim analysis of the RUBY trial. Presented at the European Hematology Association (EHA) Annual Congress. June 13-16, 2024.
June 14, 2024
H. Frangoul, M.D., M.S., et al. Reni-cel, the first AsCas12a gene-edited cell therapy, shows promising preliminary results in key clinical outcomes in transfusion-dependent beta thalassemia patients treated in the EdiThal trial. Presented at the European Hematology Association (EHA) Annual Congress. June 13-16, 2024.
May 11, 2024
MacLeod, Heather. LNP-Based Delivery of CRISPR/Cas12a for the Potential Treatment of Myocilin-Associated Glaucoma. Presented at The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 7-11, 2024.
May 10, 2024
Li, Hui, et al. Metagenomic Discovery and Screening of Novel Recombinase Proteins for Targeted Integration. Presented at The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 7-11, 2024.
May 9, 2024
Wrighton, Paul J., et al. Chemically Modified AsCas12a Guide RNAs Improve Lipid Nanoparticle–Mediated In Vivo Gene Editing in Different Tissues. Presented at The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 7-11, 2024.
February 22, 2024
H. Frangoul, MD, et al, AsCas12a gene editing of HBG1/2 promoters with EDIT-301 (reni-cel) results in rapid and sustained normalization of hemoglobin and increased fetal hemoglobin in patients with severe sickle cell disease and transfusion-dependent beta-thalassemia. Presented at the 2024 Tandem Meetings of ASTCT and CIBMTR. February 21-24, 2024.
January 25, 2024
L.I. Jansson-Fritzberg, et al. Characterizing a more efficient AsCas12a. Presented at the Precision Genome Engineering Keystone Symposia: Delivery of Nucleic Acid Therapeutics. January 22-25, 2024.
December 11, 2023
R. Hanna, M.D., et al. AsCas12a gene editing of HBG1/2 promoters with EDIT-301 results in rapid and sustained normalization of hemoglobin and increased fetal hemoglobin in patients with severe sickle cell disease and transfusion-dependent beta-thalassemia. Presented at the American Society of Hematology (ASH) Annual Meeting and Exposition. December 9-12, 2023.
December 11, 2023
EDIT-301 Program Update: RUBY and EdiTHAL Trial Data Update. Presented in a Company-sponsored Webinar. December 11, 2023.
October 30, 2023
JN Lemercier. Characterization of guide RNAs for CRISPR Applications. Presented at The 2023 CRISPR-Based Therapy Analytical Development Summit. October 30 – November 1, 2023.
June 12, 2023
EDIT-301 Program Update: RUBY and EdiTHAL Trial Data Update. Presented in a Company-sponsored Virtual Event. June 12, 2023.
June 10, 2023
R. Hanna, M.D., et al. EDIT-301 Shows Promising Preliminary Safety and Efficacy Results in the Phase I/II Clinical Trial (RUBY) of Patients with Severe Sickle Cell Disease Using Highly Specific and Efficient AsCas12a Enzyme. Presented at the European Hematology Association Hybrid Congress. June 8 -16, 2023.
May 17, 2023
Bright S. Ashimatey, et al. Twelve-month Natural History Study of CEP290-associated Retinal Degeneration. Presented at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting. April 23 – 27, 2023.
December 1, 2022
Pavlina Wolf. PCR Methods for the Characterization of AAV-based Drug Product from Titer to Potency. Presented at Gene Therapy Analytical Development 2022. November 30, 2022.
November 10, 2022
Alexander G. Allen, et al. EDIT-202, a multiplexed AsCas12a-edited iPSC-differentiated iNK, displays a mature phenotype, high KIR expression, and ADCC towards multiple solid tumor lines. Presented at The Society for Immunotherapy of Cancer (SITC) Annual Meeting, November 8-12, 2022.
October 19, 2022
Michael Nehil. Genetic Editing of iNK Cell Therapies to Enhance Tumor Killing Capacity. Presented at The iPSC-Derived Immunotherapies Congress 2022. October 19, 2022.
October 13, 2022
Mariacarmela Allocca, et al. A Mutation-Independent CRISPR/Cas9-based ‘Knockout and Replace’ Strategy to Treat Rhodopsin-Associated Autosomal Dominant Retinitis Pigmentosa. Presented at The European Society of Gene and Cell Therapy (ESGCT) Annual Meeting, October 11-14, 2022.
October 13, 2022
Samia Q. Khan, et al. EDIT-202, an AsCas12a and SLEEK™ gene-edited iPSC-derived NK cell therapy maintains prolonged persistence, high cytotoxicity, and enhanced in vivo control of solid tumors. Presented at The European Society of Gene and Cell Therapy (ESGCT) Annual Meeting, October 11-14, 2022.
August 26, 2022
Ramya Viswanathan, et al. SLEEK—A Method for Highly Efficient Knock-in and Expression of Transgene Cargos for Next-generation Cell-based Medicines. Presented at Cold Spring Harbor Laboratory’s Genome Engineering: CRISPR Frontiers meeting, August 24-27, 2022.
August 25, 2022
Chrysa Latrick, et al. Elucidating the impact of RNA secondary structure on RNP behavior. Presented at Cold Spring Harbor Laboratory’s Genome Engineering: CRISPR Frontiers meeting, August 24-27, 2022.
August 25, 2022
Bryant Chica, et al. Characterization of CRISPR RNPs by Intrinsic Fluorescence and Ion Exchange Chromatography. Presented at Cold Spring Harbor Laboratory’s Genome Engineering: CRISPR Frontiers meeting, August 24-27, 2022.
June 3, 2022
Steven Wolk. Characterization of gRNAs and Ribonucleoproteins for CRISPR Applications. Presented at Gene Therapy Analytical Development Europe 2022, May 30 – June 1, 2022.
May 19, 2022
Zoe (Chi-Hsiu) Liu, et al. A Mutation-independent CRISPR/Cas9-based ‘Knockout and Replace’ Strategy to Treat Rhodopsin-associated Autosomal Dominant Retinitis Pigmentosa (RHO-adRP). Presented at The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 16-19, 2022.
May 18, 2022
John Zuris, et al. SLEEK: A Method for Highly Efficient Knock-in and Expression of Transgene Cargos for Next-Generation Cell-Based Medicines. Presented at The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 16-19, 2022.
May 16, 2022
Samia Q. Khan, et al. EDIT-202, a Multiplexed CRISPR-Cas12a Gene-Edited iPSC-Derived NK Cell Therapy, has Prolonged Persistence, Promotes High Cytotoxicity, and Enhances In Vivo Tumor Killing. Presented at The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 16-19, 2022.
May 16, 2022
Brian R. Duke, et al. Exploratory Immuno-Safety Profile of EDIT-101, a First-in-Human In Vivo CRISPR Gene Editing Therapy for CEP290-Related Retinal Degeneration. Presented at The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 16-19, 2022.
May 11, 2022
John Zuris. A Method for Highly Efficient Knock-in and Expression of Transgene Cargos for Next-Generation Cell-Based Medicines. Presented at TIDES USA Oligonucleotide & Peptide Therapeutics. May 9 – 13, 2022.
May 11, 2022
Mark S. Shearman. Ongoing Progress in the Phase 1/2 BRILLIANCE Clinical Trial for Treatment of CEP-290 Retinal Degeneration: In vivo CRISPR gene editing therapies for ocular disease. Presented at TIDES USA Oligonucleotide & Peptide Therapeutics. May 9 – 13, 2022.
May 4, 2022
Zoe (Chi-Hsiu) Liu, et al. A Mutation-independent CRISPR/Cas9-based ‘Knockout and Replace’ Strategy to Treat Rhodopsin-associated Autosomal Dominant Retinitis Pigmentosa (RHO-adRP). Presented at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, May 1-4, 2022
May 1, 2022
Michael C. Jaskolka, et al. Exploratory Safety Profile of EDIT-101, a First-in-Human in vivo CRISPR Gene Editing Therapy for CEP290-Related Retinal Degeneration. Presented at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, May 1-4, 2022
April 8, 2022
Alexander G. Allen, et al. AsCas12a gene-edited iPSC-derived NK cells constitutively expressing CD16 and membrane-bound IL-15 demonstrate prolonged persistence and robust anti-tumor activities in a solid tumor mouse model. Presented at The American Association for Cancer Research (AACR) Annual Meeting 2022, April 8 – 13, 2022.
December 12, 2021
Samia Q. Khan, Alexandra Gerew, et al. Knock-out of CISH and TGFβR2 or knock-in of CD16 and mbIL-15 in iPSC-derived NK cells promotes high cytotoxicity and enhances in vivo tumor killing. Presented at The 63rd Annual Meeting and Exposition of the American Society of Hematology. December 11-14, 2021.
December 11, 2021
Patricia Sousa, et al. Preclinical development of EDIT-301, an autologous cell therapy comprising AsCas12a-RNP-modified mobilized peripheral blood CD34+ cells for the potential treatment of transfusion-dependent beta thalassemia. Presented at The 63rd Annual Meeting and Exposition of the American Society of Hematology. December 11-14, 2021.
November 12, 2021
Alexander G. Allen, et al. GAPDH knock-in of high-affinity CD16 and mbIL-15 in iPSC-derived NK cells drives high-level expression and increased anti-tumor function. Presented at The Society for Immunotherapy of Cancer (SITC) Annual Meeting 2021, November 10-14, 2021.
September 23, 2021
John Zuris. An Engineered AsCas12a Nuclease Facilitates the Rapid Generation of Therapeutic Cell Medicines. Presented at TIDES USA Oligonucleotide and Peptide Therapeutics, September 20-23, 2021.
September 23, 2021
Keith Jarvis. IND-enabling Small-Scale Guide RNA Production Under GMP for CRISPR Based Cell Therapies. Presented at TIDES USA Oligonucleotide and Peptide Therapeutics, September 20-23, 2021.
September 23, 2021
Steve Wolk. Characterization of gRNAs and Ribonucleoproteins for CRISPR Applications. Presented at TIDES USA Oligonucleotide and Peptide Therapeutics, September 20-23, 2021.
September 21, 2021
Jean-Noel Lemercier, et al. Characterization of CRISPR RNPs by Ion-Exchange Chromatography. Presented at TIDES USA Oligonucleotide and Peptide Therapeutics, September 20-23, 2021.
September 21, 2021
Pranjali Ghude, et al. Understanding CRISPR RNA Secondary Structure Impact on Ribonucleoprotein (RNP) Behavior by SEC-PAGE. Presented at TIDES USA Oligonucleotide and Peptide Therapeutics, September 20-23, 2021.
August 20, 2021
J. A. Zuris. A Method for Highly Efficient Knock-in and Expression of Transgene Cargos for Next Generation Cell-based Medicine. Presented at Cold Spring Harbor Laboratory’s Genome Engineering: CRISPR Frontiers meeting, August 18-20, 2021.
August 18, 2021
Eugenio Marco et al. CALITAS: a CRISPR-Cas-aware ALigner for In silico off-TArget Search. Presented at Cold Spring Harbor Laboratory’s Genome Engineering: CRISPR Frontiers meeting, August 18-20, 2021.
June 11, 2021
Edouard De Dreuzy, et al. Preclinical Data Supporting the Initiation of the EDIT-301 Phase I/II RUBY Clinical Trial for the Potential Treatment of Sickle Cell Disease. Presented at the 26th Congress of the European Hematology Association (EHA), June 9 – 17, 2021.
May 11, 2021
M. Allocca, D. Reyon, et al. Advances Toward a Dual AAV CRISPR-Cas9-based “Knockout and Replace” Strategy to Treat Rhodopsin-Associated Autosomal Dominant Retinitis Pigmentosa. The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 11 – 14, 2021
May 10, 2021
H. MacLeod. The development of CRISPR-based medicines for the treatment of ocular diseases. The American Society of Gene and Cell Therapy (ASGCT) Annual Meeting, May 11 – 14, 2021
May 4, 2021
N. Dilmac, et al. CRISPR Gene Editing Rescues Deficits in Human USH2A Mutant Retinal Organoids. The Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, May 1-7, 2021
May 3, 2021
M. Allocca, et al. Advances Toward a Dual AAV CRISPR-Cas9-based “Knockout and Replace” Strategy to Treat Rhodopsin-Associated Autosomal Dominant Retinitis Pigmentosa. The Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting, May 1-7, 2021
April 10, 2021
K. Wong, et al. CRISPR-Cas12a Gene Editing Enhances Functional Metabolism of Natural Killer Cells and Enables Tumor Cell Cytolysis in Metabolically Stressful Conditions That Inhibit Effector Cell Function. Presented at the American Association for Cancer Research (AACR) Annual Meeting, April 10 – 15, 2021
April 10, 2021
Christopher M. Borges, et al. A Multiplexed CRISPR-Cas12a Gene-Edited Healthy Donor-Derived NK Cell Therapy with Increased Granzyme B and Degranulation Supports Improved Serial Killing Capacity. Presented at the American Association for Cancer Research (AACR) Annual Meeting, April 10 – 15, 2021
December 7, 2020
Jung-Il Moon, et al. Generation of Natural Killer Cells with Enhanced Function from a CRISPR/Cas12a-Edited Induced Pluripotent Stem Cell Line. Presented at the 62nd Annual Meeting and Exposition of the American Society of Hematology (ASH), December 5-8, 2020.
December 5, 2020
Edouard De Dreuzy, et al. Robust Pre-Clinical Results and Large-Scale Manufacturing Process for EDIT-301: An Autologous Cell Therapy for the Potential Treatment of SCD. Presented at the 62nd Annual Meeting and Exposition of the American Society of Hematology (ASH), December 5-8, 2020.
December 5, 2020
Christopher M. Borges, et al. Preclinical Development of EDIT-201, a Multigene Edited Healthy Donor NK Cell with Enhanced Anti-Tumor Function and Superior Serial Killing Activity in an Immunosuppressive Environment. Presented at the 62nd Annual Meeting and Exposition of the American Society of Hematology (ASH), December 5-8, 2020.
November 9, 2020
K. Wong, et al. Preclinical Development of EDIT-201, a Multiplexed CRISPR-Cas12a Gene Edited Healthy Donor Derived NK Cell Therapy Demonstrating Improved Persistence and Resistance to the Tumor Microenvironment. Presented at The Society for Immunotherapy of Cancer (SITC) 35th Annual Meeting, November 9-14, 2020.
June 12, 2020
Jack Heath, et al. EDIT-301: An Autologous Cell Therapy to Promote Fetal Hemoglobin Expression for the Potential Treatment of Sickle Cell Disease. Presented at the 25th Congress of the European Hematology Association (EHA), June 11-21, 2020.
May 15, 2020
J.A. Zuris, et al. Highly Efficient Multi-Gene Knockout and Transgene Knock-in using CRISPR-Cas12a in Induced Pluripotent Stem Cells for the Generation of Engineered Cell Immunotherapies. Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.
May 13, 2020
Swati Mukherjee, et al. In Vivo Proof of Concept for EDIT-102: A CRISPR/Cas9-Based Experimental Medicine for USH2A-Related Inherited Retinal Degeneration Caused by Mutations in Exon 13. Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.
May 12, 2020
Abhishek Dass, et al. Dual AAV-based ‘Knock-out-and-replace’ of RHO as a Therapeutic Approach to Treat RHO-associated Autosomal Dominant Retinitis Pigmentosa (RHO adRP). Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.
May 12, 2020
Eugenio Marco, et al. CALITAS: a CRISPR/Cas-aware ALigner for In silico off-TArget Search. Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.
May 11, 2020
J .A. Zuris. Best Practices for Achieving Optimal Ex Vivo Genome Editing in Your Research. Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.
February 10, 2020
Richard A. Morgan. Ex vivo applications of Cas12a. Presented at the Keystone Symposia: Engineering the Genome, February 8-12, 2020.
December 7, 2019
Edouard De Dreuzy, et al. EDIT-301: An Experimental Autologous Cell Therapy Comprising Cas12a-RNP Modified mPB-CD34+ Cells for the Potential Treatment of SCD. Presented at the 61st Annual Meeting and Exposition of the American Society of Hematology (ASH). December 7-10, 2019.
October 22, 2019
C.M. Margulies, et al. Developing a CRISPR/Cas9 Editing Approach for the Treatment of USH2A Related Inherited Retinal Degeneration. Presented at the European Society for Gene and Cell Therapy 27th Annual Congress (ESGCT), October 22-25, 2019.
October 10, 2019
Gregory Gotta, et al. SaCas9 and AsCas12a (AsCpf1) are as potent and more specific than SpCas9. Presented at Cold Spring Harbor Laboratory: Genome Engineering: Frontiers of CRISPR/Cas, October 10-13, 2019.
June 13, 2019
Jack Heath, et al. Genome Editing of BG1/2Promoter Leads to Robust HbF Induction In Vivo, While Editing of BCL11A Erythroid Enhancer Results in Erythroid Defects. Presented at the 24th Congress of the European Hematology Association (EHA), June 13 – 16, 2019.
April 29, 2019
J.A. Zuris, et al. Strategies for multi-gene editing and reduction of translocations with CRISPR-Cpf1 in T cells for the development of improved cell therapies. Presented at the American Society of Gene & Cell Therapy (ASGCT) 22nd Annual Meeting, April 29 – May 2, 2019.
February 19, 2019
Vic Myer. Controlling Rearrangement Frequencies in the Context of Multigene Genome Editing. Presented at Keystone Symposia on Molecular and Cellular Biology – Genome Engineering: From Mechanisms to Therapies, February 19-23, 2019.
December 1, 2018
Kai-Hsin Chang, et al. Genome Editing of HBG1/2 Promoter Leads to Robust HbF Induction In Vivo While Editing of BCL11A Erythroid Enhancer Shows Erythroid Defect. Presented at the 60th ASH Annual Meeting & Exposition, December 1 – 4.
October 16, 2018
John A. Zuris, et al. Highly Efficient Single and Multi-gene Knockout with CRISPR-Cpf1 in T Cells for the Development of Improved Cell Therapies. Presented at the European Society of Gene & Cell Therapy (ESGCT) 26th Annual Congress, October 16 – 19.
October 16, 2018
Michael Stefanidakis, et al. Preclinical Assessment of In Vivo Gene Editing Efficiency, Specificity, and Tolerability of EDIT-101, an Investigational CRISPR Treatment for Leber Congenital Amaurosis 10 (LCA10). Presented at the European Society of Gene & Cell Therapy (ESGCT) 26th Annual Congress, October 16 – 19.
May 16, 2018
Shen Shen, et al. Treatment of Herpetic Keratitis with CRISPR/Cas9 Gene Editing in a Rabbit Disease Model. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.
May 16, 2018
G. Grant Welstead, et al. Improving Efficacy of CAR T Cells through CRISPR/Cas9 Mediated Knockout of TGF?RII. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.
May 16, 2018
Edouard de Dreuzy, et al. Potent HbF Induction Following ssODN-mediated Repair of Cas9-induced DSB at the HBG Promoter in CD34+ HSPC. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.
May 16, 2018
Kai-Hsin Chang, et al. Saturated Mutagenesis Surrounding Beta-globin Locus Identifies Novel Therapeutic Targets for Fetal Globin Induction and Treatment of Sickle Cell Anemia. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.
May 16, 2018
Carrie M. Margulies, et al. Efficient Targeted Integration in Human T Cells with CRISPR-Cas9 for the Treatment of X-Linked Hyper-IgM Syndrome. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.
May 16, 2018
Jiang H, et al. Evaluation of Tolerability and Immunogenicity of EDIT-101 Following Subretinal Injection in Non- human Primates. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.
May 16, 2018
Christopher J. Wilson, et al. Gene Editing Specificity Assessment for EDIT-101, an LCA10 Therapeutic Candidate. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.
May 7, 2018
Terence Ta. Development of High Quality CRISPR/Cas9 Agents. Presented at TIDES: Oligonucleotide and Peptide Therapeutics, May 7 – 10.
May 7, 2018
Vic Myer. gRNA Quality for CRISPR Medicines. Presented at TIDES: Oligonucleotide and Peptide Therapeutics, May 7 – 10.
April 29, 2018
Christopher M. Owens, et al. CRISPR/Cas9 Targeted Disruption of Herpes Simplex Virus type 1 in a Rabbit Latency Model Reduces Viral Reactivation and Associated Corneal Pathology. Presented at the Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting, April 29 – May 3, 2018
April 29, 2018
Michael Stefanidakis, et al. Efficient in vivo editing of CEP290 IVS26 by EDIT-101 as a novel therapeutic for the treatment of Leber Congenital Amaurosis 10. Presented at the Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting, April 29 – May 3, 2018.
April 23, 2018
Christopher Wilson. Methods for Gene Editing Measurement and Off-Target Discovery. Presented at NIST-FDA Genome Editing Workshop, April 23-24, 2018.
January 28, 2018
Charles Albright, Ph.D. Discovery of EDIT-101 for the Treatment of Leber’s Congenital Amaurosis Type 10. Presented at Keystone Symposia on Molecular and Cellular Biology: Precision Genome Editing with Programmable Nucleases, January 28 – February 1, 2018.
January 28, 2018
John Zuris. Highly efficient editing with CRISPR-Cpf1 in primary T cells and HSCs. Presented at Keystone Symposia on Molecular and Cellular Biology: Precision Genome Editing with Programmable Nucleases, January 28 – February 1, 2018.
December 9, 2017
Aditi Chalishazar, et al. Expanding CRISPR Genome Editing Strategies in Hematopoietic Stem and Progenitor Cells for the Treatment of Hematologic Diseases. Presented at the 59th ASH Annual Meeting & Exposition, December 9-12, 2017.
November 7, 2017
Cecilia Fernandez. CRISPR Genome Editing: Considerations for Therapeutic Applications. Presented at EuroTIDES, Vienna, Austria, November 7-10, 2017.
October 19, 2017
Michael Stefanidakis, et al. Development of a Subretinally Delivered CEP290-Specific CRISPR Medicine for the Treatment of Leber Congenital Amaurosis 10 (LCA10), October 19, 2017.
September 27, 2017
Junxia Wang. Development of Multiplex Sensitive Anti-Drug Antibody Assays for CRISPR/Cas9 Gene Therapies, September 27, 2017.
September 20, 2017
Grant Welstead. The Development of CRISPR Based Medicines for the Treatment of Hematological Diseases, September 20, 2017.
July 21, 2017
Cecilia Cotta-Ramusino. Characterization of Genomic Rearrangements in Response to CRISPR/Cas9-Induced Double-Stranded Breaks. Presented at Cold Spring Harbor Laboratory: Genome Engineering: The CRISPR-Cas9 Revolution, July 21-23, 2017.
July 21, 2017
Maxwell N. Skor. Therapeutic Correction of an LCA-Causing Splice Defect in the CEP290 Gene by CRISPR/Cas-Mediated Genome Editing. Presented at Cold Spring Harbor Laboratory: Genome Engineering: The CRISPR-Cas9 Revolution, July 21-23, 2017.
July 21, 2017
Eugenio Marco, et al. UDiTasTM: A streamlined genome editing detection method for on- and off-target edits, large deletions, and translocations. Presented at Cold Spring Harbor Laboratory: Genome Engineering: The CRISPR-Cas9 Revolution, July 21-23, 2017.
July 21, 2017
Eric Tillotson, et al. An in vitro method for benchmarking of CRISPR-associated endonucleases. Presented at Cold Spring Harbor Laboratory: Genome Engineering: The CRISPR-Cas9 Revolution, July 21-23, 2017.
June 22, 2017
Barrett Steinberg, et al. Directed evolution platforms and applications for engineering RNA-guided nucleases. Presented at Synthetic Biology: Engineering Evolution & Design (SEED) 2017, Vancouver, BC, June 22, 2017.
June 8, 2017
Hari Jayaram, et al. Towards predictable editing: influence of target sequence, cell type, and choice of type II nuclease on desired repair outcomes. Presented at the CRISPR 2017 International Conference, Big Sky, Montana, June 8 – 10, 2017.
June 8, 2017
Barrett Steinberg, et al. Directed evolution of Cas9 to reduce identified off-target cleavage. Presented at the CRISPR 2017 International Conference, Big Sky, Montana, June 8 – 10, 2017.
June 8, 2017
John Zuris, et al. Comparison of RNP-mediated editing by Type V Cpf1variants across multiple cell types. Presented at the CRISPR 2017 International Conference, Big Sky, Montana, June 8 – 10, 2017.
June 8, 2017
Hari Jayaram. Defining and characterizing the components of a CRISPR-Cas9 genomic medicine. Presented at the CRISPR 2017 International Conference, Big Sky, Montana, June 8 – 10, 2017.
May 13, 2017
Shannon Boye, et al. Efficient In Vivo Gene Editing of Inherited Retinal Disease Genes in Mice and Non-Human Primates. Presented at the ASGCT 20th Annual Meeting, May 13, 2017.
May 12, 2017
Georgia Giannoukos, et al. UDiTaS(TM): A streamlined genome editing detection method for on- and off-target edits, large deletions, and translocations. Presented at the ASGCT 20th Annual Meeting, May 12, 2017.
May 11, 2017
Jennifer Gori. CRISPR-mediated Editing of Hematopoietic Stem Cells for the Treatment of Beta-Hemoglobinopathies. Presented at the ASGCT 20th Annual Meeting, May 11, 2017.
May 11, 2017
Carrie M. Margulies, et al. Characterization of Targeted Integration with Viral and Non-Viral DNA Donors. Presented at the ASGCT 20th Annual Meeting, May 11, 2017.
May 11, 2017
P. Singhal, et al. Friedland. Self-inactivating Cas9: a method for reducing exposure while maintaining efficacy in virally-delivered Cas9 applications. Presented at the ASGCT 20th Annual Meeting, May 11, 2017.
May 10, 2017
Shen Shen, et al. Amelioration of Alpha-1 Antitrypsin Deficiency Diseases with Genome Editing in Transgenic Mice. Presented at the ASGCT 20th Annual Meeting, May 10, 2017.
May 7, 2017
Haiyan Jiang. Opportunities and Challenges in Development of CRISPR Medicines. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.
May 7, 2017
Derek Cerchione, et al. Directed evolution of targeted Cas9 cleavage to the LCA10 splice donor mutation. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.
May 7, 2017
Eric Tillotson, et al. Assessing Cas9-gRNA ribonucleoprotein complex formation for development of ex-vivo therapeutics. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.
May 7, 2017
Guillaume Harmange, et al. Probing the Quality of Cas9 Ribonucleoprotein Complex Using Biochemistry and Biophysics. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.
May 7, 2017
Ramya Viswanathan, et al. Comparison of RNP-mediated editing by Type V Cpf1 variants. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.
May 3, 2017
Christopher Wilson. Advancing CRISPR Technologies for Therapeutic Application. Presented at the TIDES Oligonucleotide & Peptide Therapeutics conference, May 3, 2017.
May 3, 2017
Cecilia Fernandez. Genome Editing: Considerations for Therapeutic Applications. Presented at the TIDES Oligonucleotide & Peptide Therapeutics conference, May 3, 2017.
April 15, 2017
Christopher Wilson, et al. A Genome Editing Lead Finding Platform for Therapeutics. Cambridge, MA.
April 2, 2017
Anne Bothmer, et al. DNA Repair Factor Overexpression Screen Identifies Factors Required for Repair Pathway Choice. Presented at Keystone Symposia on Molecular and Cellular Biology: Genomic Instability and DNA Repair, April 2-6, 2017.
April 2, 2017
Cecilia Cotta-Ramusino, et al. Effect of Different CRISPR/Cas9 Variants on Repair Pathway Choice. Presented at Keystone Symposia on Molecular and Cellular Biology: Genomic Instability and DNA Repair, April 2-6, 2017.
January 8, 2017
Anne Bothmer, et al. Characterization of the Interplay Between DNA Repair and CRISPR/Cas9-Induced DNA Lesions. Presented at Keystone Symposia on Molecular and Cellular Biology: Precision Genome Engineering, January 8—12, 2017.
January 5, 2017
Vic Myer. Advancing CRISPR Technologies for Therapeutic Application. Presented at the Keystone Genome Editing Meeting, January 5, 2017.
December 3, 2016
J.M. Heath, et al. Efficient CRISPR/Cas9 Mediated Gene Editing in Long-Term Engrafting Human Hematopoietic Stem Progenitor Cells. Presented at the American Society of Hematology Annual Meeting, December 3-6, 2016 in San Diego, CA.
October 18, 2016
J.M Heath, et al. Highly Efficient CRISPR/Cas9 Mediated Gene Editing in Long-Term Engrafting Human Hematopoietic Stem Progenitor CellsA. Presented at the European Society of Gene and Cell Therapy Annual Meeting, October 18-21, 2016 in Florence, Italy.
September 25, 2016
David Bumcrot. Advancing CRISPR Medicines: Challenges and Solutions. Presented at the Oligonucleotide Therapeutics Society Annual Meeting, September 25-28 in Montreal, Canada.
June 5, 2016
Morgan Maeder. Envisioning a Gene Editing Approach to Treat Inherited Blindness. Presented at the Federation of American Societies For Experimental Biology, June 5-10 in Lisbon, Portugal.
May 4, 2016
Grant Welstead, et al. Successful Generation of CAR+PD-1- Primary T Cells Using Cas9-Mediated Genome Editing. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.
May 4, 2016
Tanushree Phadke, et al. DNA Ends Matter: The Impact of Using CRISPR/Cas9 Variants on DNA Repair Pathway Choice and Editing Profiles at The HBB Locus. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.
May 4, 2016
Josh Tycko, et al. Screening S. aureus CRISPR-Cas9 Paired Guide RNAs for Efficient Targeted Deletion in Duchenne Muscular Dystrophy. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.
May 4, 2016
Morgan L. Maeder, et al. Therapeutic Correction of an LCA-Causing Splice Defect in the CEP290 Gene by CRISPR/Cas-Mediated Genome Editing. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.
May 4, 2016
J. M. Heath, et al. Highly Efficient CRISPR/Cas9 Gene Editing and Long-Term Engraftment of Human Hematopoietic Stem and Progenitor Cells. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.
May 1, 2016
Morgan L. Maeder, et al. Therapeutic Correction of an LCA-Causing Splice Defect in the CEP290 Gene by CRISPR/Cas-Mediated Genome Editing. Presented at the Association for Research in Vision and Ophthalmology (ARVO), May 1-5, 2016 in Seattle, WA.
May 15, 2015
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May 15, 2015
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May 14, 2015
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May 13, 2015
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May 13, 2015
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March 2, 2015
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January 12, 2015
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January 11, 2015
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October 22, 2013
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October 9, 2013
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September 8, 2013
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August 29, 2013
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August 26, 2013
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August 20, 2013
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August 14, 2013
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August 11, 2013
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August 9, 2013
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August 8, 2013
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August 1, 2013
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July 31, 2013
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July 25, 2013
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July 23, 2013
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July 21, 2013
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July 11, 2013
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July 9, 2013
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July 1, 2013
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June 30, 2013
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June 23, 2013
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June 18, 2013
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June 12, 2013
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April 2, 2013
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April 2, 2013
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April 2, 2013
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March 10, 2013
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March 7, 2013
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March 4, 2013
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February 28, 2013
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January 29, 2013
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January 29, 2013
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January 3, 2013
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January 3, 2013
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January 1, 2013
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January 1, 2013
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October 1, 2012
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August 3, 2012
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July 1, 2012
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June 28, 2012
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