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June 12, 2020

Jack Heath, et al. EDIT-301: An Autologous Cell Therapy to Promote Fetal Hemoglobin Expression for the Potential Treatment of Sickle Cell Disease. Presented at the 25th Congress of the European Hematology Association (EHA), June 11-21, 2020.

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May 15, 2020

J.A. Zuris, et al. Highly Efficient Multi-Gene Knockout and Transgene Knock-in using CRISPR-Cas12a in Induced Pluripotent Stem Cells for the Generation of Engineered Cell Immunotherapies. Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.

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May 13, 2020

Swati Mukherjee, et al. In Vivo Proof of Concept for EDIT-102: A CRISPR/Cas9-Based Experimental Medicine for USH2A-Related Inherited Retinal Degeneration Caused by Mutations in Exon 13. Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.

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May 12, 2020

Abhishek Dass, et al. Dual AAV-based ‘Knock-out-and-replace’ of RHO as a Therapeutic Approach to Treat RHO-associated Autosomal Dominant Retinitis Pigmentosa (RHO adRP). Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.

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May 12, 2020

Eugenio Marco, et al. CALITAS: a CRISPR/Cas-aware ALigner for In silico off-TArget Search. Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.

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May 11, 2020

J .A. Zuris. Best Practices for Achieving Optimal Ex Vivo Genome Editing in Your Research. Presented at the 23rd ASGCT Annual Meeting, May 12-15, 2020.

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February 10, 2020

Richard A. Morgan. Ex vivo applications of Cas12a. Presented at the Keystone Symposia: Engineering the Genome, February 8-12, 2020.

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December 7, 2019

Edouard De Dreuzy, et al. EDIT-301: An Experimental Autologous Cell Therapy Comprising Cas12a-RNP Modified mPB-CD34+ Cells for the Potential Treatment of SCD. Presented at the 61st Annual Meeting and Exposition of the American Society of Hematology (ASH). December 7-10, 2019.

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October 22, 2019

C.M. Margulies, et al. Developing a CRISPR/Cas9 Editing Approach for the Treatment of USH2A Related Inherited Retinal Degeneration. Presented at the European Society for Gene and Cell Therapy 27th Annual Congress (ESGCT), October 22-25, 2019.

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October 10, 2019

Gregory Gotta, et al. SaCas9 and AsCas12a (AsCpf1) are as potent and more specific than SpCas9. Presented at Cold Spring Harbor Laboratory: Genome Engineering: Frontiers of CRISPR/Cas, October 10-13, 2019.

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June 13, 2019

Jack Heath, et al. Genome Editing of BG1/2Promoter Leads to Robust HbF Induction In Vivo, While Editing of BCL11A Erythroid Enhancer Results in Erythroid Defects. Presented at the 24th Congress of the European Hematology Association (EHA), June 13 – 16, 2019.

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April 29, 2019

J.A. Zuris, et al. Strategies for multi-gene editing and reduction of translocations with CRISPR-Cpf1 in T cells for the development of improved cell therapies. Presented at the American Society of Gene & Cell Therapy (ASGCT) 22nd Annual Meeting, April 29 – May 2, 2019.

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February 19, 2019

Vic Myer. Controlling Rearrangement Frequencies in the Context of Multigene Genome Editing. Presented at Keystone Symposia on Molecular and Cellular Biology – Genome Engineering: From Mechanisms to Therapies, February 19-23, 2019.

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December 1, 2018

Kai-Hsin Chang, et al. Genome Editing of HBG1/2 Promoter Leads to Robust HbF Induction In Vivo While Editing of BCL11A Erythroid Enhancer Shows Erythroid Defect. Presented at the 60th ASH Annual Meeting & Exposition, December 1 – 4.

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October 16, 2018

John A. Zuris, et al. Highly Efficient Single and Multi-gene Knockout with CRISPR-Cpf1 in T Cells for the Development of Improved Cell Therapies. Presented at the European Society of Gene & Cell Therapy (ESGCT) 26th Annual Congress, October 16 – 19.

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October 16, 2018

Michael Stefanidakis, et al. Preclinical Assessment of In Vivo Gene Editing Efficiency, Specificity, and Tolerability of EDIT-101, an Investigational CRISPR Treatment for Leber Congenital Amaurosis 10 (LCA10). Presented at the European Society of Gene & Cell Therapy (ESGCT) 26th Annual Congress, October 16 – 19.

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May 16, 2018

Shen Shen, et al. Treatment of Herpetic Keratitis with CRISPR/Cas9 Gene Editing in a Rabbit Disease Model. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.

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May 16, 2018

G. Grant Welstead, et al. Improving Efficacy of CAR T Cells through CRISPR/Cas9 Mediated Knockout of TGF?RII. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.

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May 16, 2018

Edouard de Dreuzy, et al. Potent HbF Induction Following ssODN-mediated Repair of Cas9-induced DSB at the HBG Promoter in CD34+ HSPC. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.

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May 16, 2018

Kai-Hsin Chang, et al. Saturated Mutagenesis Surrounding Beta-globin Locus Identifies Novel Therapeutic Targets for Fetal Globin Induction and Treatment of Sickle Cell Anemia. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.

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May 16, 2018

Carrie M. Margulies, et al. Efficient Targeted Integration in Human T Cells with CRISPR-Cas9 for the Treatment of X-Linked Hyper-IgM Syndrome. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.

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May 16, 2018

Jiang H, et al. Evaluation of Tolerability and Immunogenicity of EDIT-101 Following Subretinal Injection in Non- human Primates. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.

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May 16, 2018

Christopher J. Wilson, et al. Gene Editing Specificity Assessment for EDIT-101, an LCA10 Therapeutic Candidate. Presented at the American Society of Gene & Cell Therapy (ASGCT) 21st Annual Meeting, May 16 – 19.

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May 7, 2018

Terence Ta. Development of High Quality CRISPR/Cas9 Agents. Presented at TIDES: Oligonucleotide and Peptide Therapeutics, May 7 – 10.

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May 7, 2018

Vic Myer. gRNA Quality for CRISPR Medicines. Presented at TIDES: Oligonucleotide and Peptide Therapeutics, May 7 – 10.

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April 29, 2018

Christopher M. Owens, et al. CRISPR/Cas9 Targeted Disruption of Herpes Simplex Virus type 1 in a Rabbit Latency Model Reduces Viral Reactivation and Associated Corneal Pathology. Presented at the Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting, April 29 – May 3, 2018

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April 29, 2018

Michael Stefanidakis, et al. Efficient in vivo editing of CEP290 IVS26 by EDIT-101 as a novel therapeutic for the treatment of Leber Congenital Amaurosis 10. Presented at the Association for Research in Vision and Ophthalmology (ARVO) 2018 Annual Meeting, April 29 – May 3, 2018.

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April 23, 2018

Christopher Wilson. Methods for Gene Editing Measurement and Off-Target Discovery. Presented at NIST-FDA Genome Editing Workshop, April 23-24, 2018.

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January 28, 2018

Charles Albright, Ph.D. Discovery of EDIT-101 for the Treatment of Leber’s Congenital Amaurosis Type 10. Presented at Keystone Symposia on Molecular and Cellular Biology: Precision Genome Editing with Programmable Nucleases, January 28 – February 1, 2018.

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January 28, 2018

John Zuris. Highly efficient editing with CRISPR-Cpf1 in primary T cells and HSCs. Presented at Keystone Symposia on Molecular and Cellular Biology: Precision Genome Editing with Programmable Nucleases, January 28 – February 1, 2018.

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December 9, 2017

Aditi Chalishazar, et al. Expanding CRISPR Genome Editing Strategies in Hematopoietic Stem and Progenitor Cells for the Treatment of Hematologic Diseases. Presented at the 59th ASH Annual Meeting & Exposition, December 9-12, 2017.

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November 7, 2017

Cecilia Fernandez. CRISPR Genome Editing: Considerations for Therapeutic Applications. Presented at EuroTIDES, Vienna, Austria, November 7-10, 2017.

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October 19, 2017

Michael Stefanidakis, et al. Development of a Subretinally Delivered CEP290-Specific CRISPR Medicine for the Treatment of Leber Congenital Amaurosis 10 (LCA10), October 19, 2017.

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September 27, 2017

Junxia Wang. Development of Multiplex Sensitive Anti-Drug Antibody Assays for CRISPR/Cas9 Gene Therapies, September 27, 2017.

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September 20, 2017

Grant Welstead. The Development of CRISPR Based Medicines for the Treatment of Hematological Diseases, September 20, 2017.

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July 21, 2017

Cecilia Cotta-Ramusino. Characterization of Genomic Rearrangements in Response to CRISPR/Cas9-Induced Double-Stranded Breaks. Presented at Cold Spring Harbor Laboratory: Genome Engineering: The CRISPR-Cas9 Revolution, July 21-23, 2017.

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July 21, 2017

Maxwell N. Skor. Therapeutic Correction of an LCA-Causing Splice Defect in the CEP290 Gene by CRISPR/Cas-Mediated Genome Editing. Presented at Cold Spring Harbor Laboratory: Genome Engineering: The CRISPR-Cas9 Revolution, July 21-23, 2017.

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July 21, 2017

Eugenio Marco, et al. UDiTasTM: A streamlined genome editing detection method for on- and off-target edits, large deletions, and translocations. Presented at Cold Spring Harbor Laboratory: Genome Engineering: The CRISPR-Cas9 Revolution, July 21-23, 2017.

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July 21, 2017

Eric Tillotson, et al. An in vitro method for benchmarking of CRISPR-associated endonucleases. Presented at Cold Spring Harbor Laboratory: Genome Engineering: The CRISPR-Cas9 Revolution, July 21-23, 2017.

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June 22, 2017

Barrett Steinberg, et al. Directed evolution platforms and applications for engineering RNA-guided nucleases. Presented at Synthetic Biology: Engineering Evolution & Design (SEED) 2017, Vancouver, BC, June 22, 2017.

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June 8, 2017

Hari Jayaram, et al. Towards predictable editing: influence of target sequence, cell type, and choice of type II nuclease on desired repair outcomes. Presented at the CRISPR 2017 International Conference, Big Sky, Montana, June 8 – 10, 2017.

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June 8, 2017

Barrett Steinberg, et al. Directed evolution of Cas9 to reduce identified off-target cleavage. Presented at the CRISPR 2017 International Conference, Big Sky, Montana, June 8 – 10, 2017.

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June 8, 2017

John Zuris, et al. Comparison of RNP-mediated editing by Type V Cpf1variants across multiple cell types. Presented at the CRISPR 2017 International Conference, Big Sky, Montana, June 8 – 10, 2017.

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June 8, 2017

Hari Jayaram. Defining and characterizing the components of a CRISPR-Cas9 genomic medicine. Presented at the CRISPR 2017 International Conference, Big Sky, Montana, June 8 – 10, 2017.

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May 13, 2017

Shannon Boye, et al. Efficient In Vivo Gene Editing of Inherited Retinal Disease Genes in Mice and Non-Human Primates. Presented at the ASGCT 20th Annual Meeting, May 13, 2017.

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May 12, 2017

Georgia Giannoukos, et al. UDiTaS(TM): A streamlined genome editing detection method for on- and off-target edits, large deletions, and translocations. Presented at the ASGCT 20th Annual Meeting, May 12, 2017.

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May 11, 2017

Jennifer Gori. CRISPR-mediated Editing of Hematopoietic Stem Cells for the Treatment of Beta-Hemoglobinopathies. Presented at the ASGCT 20th Annual Meeting, May 11, 2017.

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May 11, 2017

Carrie M. Margulies, et al. Characterization of Targeted Integration with Viral and Non-Viral DNA Donors. Presented at the ASGCT 20th Annual Meeting, May 11, 2017.

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May 11, 2017

P. Singhal, et al. Friedland. Self-inactivating Cas9: a method for reducing exposure while maintaining efficacy in virally-delivered Cas9 applications. Presented at the ASGCT 20th Annual Meeting, May 11, 2017.

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May 10, 2017

Shen Shen, et al. Amelioration of Alpha-1 Antitrypsin Deficiency Diseases with Genome Editing in Transgenic Mice. Presented at the ASGCT 20th Annual Meeting, May 10, 2017.

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May 7, 2017

Haiyan Jiang. Opportunities and Challenges in Development of CRISPR Medicines. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.

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May 7, 2017

Derek Cerchione, et al. Directed evolution of targeted Cas9 cleavage to the LCA10 splice donor mutation. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.

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May 7, 2017

Eric Tillotson, et al. Assessing Cas9-gRNA ribonucleoprotein complex formation for development of ex-vivo therapeutics. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.

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May 7, 2017

Guillaume Harmange, et al. Probing the Quality of Cas9 Ribonucleoprotein Complex Using Biochemistry and Biophysics. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.

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May 7, 2017

Ramya Viswanathan, et al. Comparison of RNP-mediated editing by Type V Cpf1 variants. Presented at Broad Institute Genome Engineering 5.0, May 7-9, 2017.

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May 3, 2017

Christopher Wilson. Advancing CRISPR Technologies for Therapeutic Application. Presented at the TIDES Oligonucleotide & Peptide Therapeutics conference, May 3, 2017.

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May 3, 2017

Cecilia Fernandez. Genome Editing: Considerations for Therapeutic Applications. Presented at the TIDES Oligonucleotide & Peptide Therapeutics conference, May 3, 2017.

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April 15, 2017

Christopher Wilson, et al. A Genome Editing Lead Finding Platform for Therapeutics. Cambridge, MA.

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April 2, 2017

Anne Bothmer, et al. DNA Repair Factor Overexpression Screen Identifies Factors Required for Repair Pathway Choice. Presented at Keystone Symposia on Molecular and Cellular Biology: Genomic Instability and DNA Repair, April 2-6, 2017.

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April 2, 2017

Cecilia Cotta-Ramusino, et al. Effect of Different CRISPR/Cas9 Variants on Repair Pathway Choice. Presented at Keystone Symposia on Molecular and Cellular Biology: Genomic Instability and DNA Repair, April 2-6, 2017.

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January 8, 2017

Anne Bothmer, et al. Characterization of the Interplay Between DNA Repair and CRISPR/Cas9-Induced DNA Lesions. Presented at Keystone Symposia on Molecular and Cellular Biology: Precision Genome Engineering, January 8—12, 2017.

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January 5, 2017

Vic Myer. Advancing CRISPR Technologies for Therapeutic Application. Presented at the Keystone Genome Editing Meeting, January 5, 2017.

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December 3, 2016

J.M. Heath, et al. Efficient CRISPR/Cas9 Mediated Gene Editing in Long-Term Engrafting Human Hematopoietic Stem Progenitor Cells. Presented at the American Society of Hematology Annual Meeting, December 3-6, 2016 in San Diego, CA.

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October 18, 2016

J.M Heath, et al. Highly Efficient CRISPR/Cas9 Mediated Gene Editing in Long-Term Engrafting Human Hematopoietic Stem Progenitor CellsA. Presented at the European Society of Gene and Cell Therapy Annual Meeting, October 18-21, 2016 in Florence, Italy.

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September 25, 2016

David Bumcrot. Advancing CRISPR Medicines: Challenges and Solutions. Presented at the Oligonucleotide Therapeutics Society Annual Meeting, September 25-28 in Montreal, Canada.

June 5, 2016

Morgan Maeder. Envisioning a Gene Editing Approach to Treat Inherited Blindness. Presented at the Federation of American Societies For Experimental Biology, June 5-10 in Lisbon, Portugal.

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May 4, 2016

Grant Welstead, et al. Successful Generation of CAR+PD-1- Primary T Cells Using Cas9-Mediated Genome Editing. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.

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May 4, 2016

Tanushree Phadke, et al. DNA Ends Matter: The Impact of Using CRISPR/Cas9 Variants on DNA Repair Pathway Choice and Editing Profiles at The HBB Locus. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.

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May 4, 2016

Josh Tycko, et al. Screening S. aureus CRISPR-Cas9 Paired Guide RNAs for Efficient Targeted Deletion in Duchenne Muscular Dystrophy. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.

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May 4, 2016

Morgan L. Maeder, et al. Therapeutic Correction of an LCA-Causing Splice Defect in the CEP290 Gene by CRISPR/Cas-Mediated Genome Editing. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.

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May 4, 2016

J. M. Heath, et al. Highly Efficient CRISPR/Cas9 Gene Editing and Long-Term Engraftment of Human Hematopoietic Stem and Progenitor Cells. Presented at the American Society of Gene and Cell Therapy Annual Meeting, May 4-7, 2016 in Washington, D.C.

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May 1, 2016

Morgan L. Maeder, et al. Therapeutic Correction of an LCA-Causing Splice Defect in the CEP290 Gene by CRISPR/Cas-Mediated Genome Editing. Presented at the Association for Research in Vision and Ophthalmology (ARVO), May 1-5, 2016 in Seattle, WA.

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May 15, 2015

C. Cotta-Ramusino, et al. Therapeutic Editing of the HBB Locus Using the Endogenous HBD Locus as a Donor Template. Presented at the 18th Annual American Society of Gene & Cell Therapy (ASGCT) Meeting, May 15, 2015.

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May 15, 2015

A.E. Friedland, et al. Staphyloccocus aureus Cas9 an alternative Cas9 for genome editing applications. Presented at the 18th Annual American Society of Gene & Cell Therapy (ASGCT) Meeting, May 15, 2015.

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May 14, 2015

G. Grant Welstead, et al. Characterization of Cas9-mediated genome editing in human T cells. Presented at the 18th Annual American Society of Gene & Cell Therapy (ASGCT) Meeting, May 14, 2015.

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May 13, 2015

William Selleck, et al. Biophysical Characterization and Direct Delivery of S. pyogenes Cas9 Ribonucleoprotein Complexes. Presented at the 18th Annual American Society of Gene & Cell Therapy (ASGCT) Meeting, May 13, 2015.

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May 13, 2015

J.L. Gori, et al. Cas9-mediated genome editing in hematopoietic stem/progenitor cells. Presented at the 18th Annual American Society of Gene & Cell Therapy (ASGCT) Meeting, May 13, 2015.

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March 2, 2015

C. Cotta-Ramusino, et al. Gene targeting of the HBB locus by Crispr/Cas9 to investigate repair pathway choice in response to different types of DNA lesions. Presented at Keystone Symposium for Genomic Instability and DNA Repair, March 2, 2015.

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January 12, 2015

A.E. Friedland, et al. Staphyloccocus aureus Cas9: An alternative Cas9 for genome editing applications. Presented at Keystone Symposium for Precision Genome Engineering and Synthetic Biology, January 12, 2015.

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January 11, 2015

A.E. Friedland, et al. Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications. Published in Genome Biology (2015) 16:257.

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December 10, 2014

Konermann, S., et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. NCBI, December 10, 2014. doi:10.1038/nature14136. [Epub ahead of print]

October 30, 2014

Zuris, J.A., et al. Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo. Nature Biotechnology, October 30, 2014. doi: 10.1038/nbt.3081. [E-pub ahead of print]

October 19, 2014

Swiech, L., et al. In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9. Nature Biotechnology, October 19, 2014. doi: 10.1038/nbt.3055. [E-pub ahead of print]

October 9, 2014

Platt, R.J., et al. CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling. Cell, October 9, 2014. doi: http://dx.doi.org/10.1016/j.cell.2014.09.014. [E-pub ahead of print]

September 28, 2014

O’Connell, M.R., et al. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature, September 28, 2014. doi: 10.1038/nature13769. [E-pub ahead of print]

August 11, 2014

Sanjana, N.E., et al. Improved vectors and genome-wide libraries for CRISPR screening. Nature Methods, August 11, 2014. doi:10.1038/nmeth.3047. [E-pub ahead of print]

July 1, 2014

Guell, M., et al. Genome editing assessment using CRISPR Genome Analyzer (CRISPR-GA). Bioinformatics, July 1, 2014. doi: 10.1093/bioinformatics/btu427. [E-pub ahead of print]

June 6, 2014

Hsu, P.D., et al. Development and Applications of CRISPR-Cas9 for Genome Engineering. Cell, June 6, 2014. doi: http://dx.doi.org/10.1016/j.cell.2014.05.010. [E-pub ahead of print]

April 25, 2014

Guilinger, J.P., et al. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nature Biotechnology, April 25, 2014. doi:10.1038/nbt.2909. [E-pub ahead of print]

April 25, 2014

Tsai, S.Q., et al. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nature Biotechnology, April 25, 2014. doi:10.1038/nbt.2908. [E-pub ahead of print]

March 2, 2014

Sander, J.D., et al. CRISPR-Cas systems for editing, regulating and targeting genomes. Nature Biotechnology, March 2, 2014. doi:10.1038/ntb.2842. [E-pub ahead of print]

February 13, 2014

Nishimasu, H., et al. Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA. Cell, Feb. 13, 2014. DOI: 10.1016/j.cell.2014.02.001. [E-pub ahead of print]

February 6, 2014

Jinek, M., et al. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science, Feb. 6, 2014. DOI: 10.1126/science.1247997. [Epub ahead of print]

January 26, 2014

Fu Y., et al. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nature Biotechnology, 2014 Jan 26; doi: 10.1038/nbt2808. [Epub ahead of print]

January 1, 2014

Sternberg, et al. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature (2014) doi:10.1038/nature13011. [Epub ahead of print]

December 12, 2013

O. Shalem, et al. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells. Science. doi: 10.1126/science.1247005. Epub 2013 Dec 12.

November 10, 2013

K.M. Esvelt, et al. Church. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods. 2013 Nov;10(11):1116-21.

October 22, 2013

O. Niewoehner, et al. Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases. Nucleic Acids Res. 2013 Oct 22

October 10, 2013

P. Mali, et al. Cas9 as a versatile tool for engineering biology. Nat Methods. 2013 Oct;10(10):957-63.

October 9, 2013

M.L. Maeder, et al. Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol. 2013 Dec;31(12):1137-42. doi: 10.1038/nbt.2726. Epub 2013 Oct 9.

October 3, 2013

Y. Qi, et al. Targeted deletion and inversion of tandemly arrayed genes in Arabidopsis thaliana using zinc finger nucleases. G3 (Bethesda). 2013 Oct 3;3(10):1707-15.

September 8, 2013

E.M. Mendenhall, et al. Locus-specific editing of histone modifications at endogenous enhancers. Nat Biotechnol. 2013 Dec;31(12):1133-6. doi: 10.1038/nbt.2701. Epub 2013 Sep 8.

August 29, 2013

F.A. Ran, et al. Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity. Cell. 2013 Aug 29. doi:10.1016/j.cell.2013.08.021.

August 26, 2013

Y.B. Tzur, et al. Heritable Custom Genomic Modifications in Caenorhabditis elegans via a CRISPR–Cas9 System. Genetics. Advance online publication. 2013 Aug 26. doi:10.1534/genetics.113.156075.

August 20, 2013

Z. Feng, et al. Efficient genome editing in plants using a CRISPR/Cas system. Cell Research. 2013 Aug 20. doi:10.1038/cr.2013.114.

August 14, 2013

J.D. Sander, et al. In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites. Nucleic Acids Research. 2013 Aug 14. doi:10.1093/nar/gkt716.

August 11, 2013

V. Pattanayak, et al. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nature Biotechnology. 2013 Aug 11. doi:10.1038/nbt.2673.

August 9, 2013

T. Lo, et al. Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions. Genetics. Advance online publication. 2013 Aug 9. doi:10.1534/genetics.113.155382.

August 8, 2013

J. Li, et al. Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nature Biotechnology. 2013 Aug 8. doi:10.1038/nbt.2654.

August 1, 2013

P. Mali, et al. CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nature Biotechnology. 2013 Aug 1. doi:10.1038/nbt.2675.

July 31, 2013

L. Yang, et al. Optimization of scarless human stem cell genome editing. Nucleic Acids Research. 2013 July 31. doi: 10.1093/nar/gkt555.

July 25, 2013

M.L. Maeder, et al. CRISPR RNA–guided activation of endogenous human genes. Nature Methods. 2013 July 25. doi:10.1038/nmeth.2598.

July 23, 2013

S. Konermann, et al. Optical control of mammalian endogenous transcription and epigenetic states. Nature. 2013 July 23. doi:10.1038/nature12466.

July 21, 2013

P.D. Hsu, et al. DNA targeting specificity of RNA-guided Cas9 nucleases. Nature Biotechnology. 2013 July 21. doi:10.1038/nbt.2647.

July 11, 2013

L.A. Gilbert, et al. CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes. Cell. 2013 July 11.10.1016/j.cell.2013.06.044.

July 9, 2013

W.Y. Hwang, et al. Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System. PLOS One. 2013 July 9. doi: 10.1371/journal.pone.0068708.

July 1, 2013

D. Reyon, et al. Engineering Customized TALE Nucleases (TALENs) and TALE Transcription Factors by Fast Ligation-Based Automatable Solid-Phase High-Throughput (FLASH) Assembly. Current Protocols in Molecular Biology. 2013 July 1. doi:10.1002/0471142727.mb1216s103.

June 30, 2013

A.E. Friedland, et al. Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nature Methods. 2013 June 30. doi:10.1038/nmeth.2532.

June 23, 2013

Y. Fu, et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nature Biotechnology. 2013 June 23. doi:10.1038/nbt.2623.

June 18, 2013

X. Li, et al. piggyBac transposase tools for genome engineering. Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2279-87.

June 12, 2013

D. Bikard, et al. Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Research. 2013 June 12. doi: 10.1093/nar/gkt520.

April 2, 2013

H.Wang, et al. One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering. 2013 May 2. doi:10.1016/j.cell.2013.04.025.

April 2, 2013

M.J. Osborn, et al. TALEN-based Gene Correction for Epidermolysis Bullosa. Molecular Therapy. 2013 April 2. doi:10.1038/mt.2013.56.

April 2, 2013

H.Y. Lee, et al. RNA-protein analysis using a conditional CRISPR nuclease. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5416-21.

March 10, 2013

M.L. Maeder, et al. Robust, synergistic regulation of human gene expression using TALE activators. Nat Methods. 2013 March 10. doi: 10.1038/nmeth.2366.

March 7, 2013

E. Charpentier, et al. Biotechnology: Rewriting a genome. Nature. 2013 Mar 7;495(7439):50-1.

March 4, 2013

J.E. DiCarlo, et al. Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems. Nucleic Acids Research. 2013 March 4. doi: 10.1093/nar/gkt135.

February 28, 2013

L.S. Qi, et al. Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression. Cell. 28 February 2013. 10.1016/j.cell.2013.02.022.

January 29, 2013

W.Y. Hwang, et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nature Biotechnology. 2013 Jan 29. doi:10.1038/nbt.2501.

January 29, 2013

W. Jiang, et al. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nature Biotechnology. 2013 January 29. doi:10.1038/nbt.2508.

January 3, 2013

P. Mali, et al. RNA-Guided Human Genome Engineering via Cas9. Science. 2013 Jan 3. doi:10.1126/science.1232033.

January 3, 2013

L. Cong, et al. Multiplex Genome Engineering Using CRISPR/Cas Systems. Science. 2013 Jan 3. doi:10.1126/science.1231143.

January 1, 2013

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